Valdivia Laboratory

Publications

Link to publications on PubMed

 

Selected publications:

  1. Alvarado FJ, Bos JM, Yuchi Z, Valdivia CR, Hernandez JJ, Zhao YT, Henderlong DS, Chen Y, Booher TR, Marcou CA, Van Petegem F, Ackerman MJ, Valvidia HH. Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2. JCI Insight 4, e126544 (2019). [Link]
  2. Potenza DM, Janicek R, Fernandez-Tenorio M, Camors E, Ramos-Mondragón R, Valdivia HH, Niggli E. Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response. J Gen Physiol 151, 131-145 (2019). [Link]
  3. Ponce-Balbuena D, Guerrero-Serna G, Valdivia CR, Caballero R, Diez-Guerra FJ, Jiménez-Vázquez EN, Ramírez RJ, Monteiro da Rocha A, Herron TJ, Campbell KF, Willis BC, Alvarado FJ, Zarzoso M, Kaur K, Pérez-Hernández M, Matamoros M, Valdivia HH, Delpón E, Jalife J. Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability. Circ Res 122, 1501-1516 (2018). [Link]
  4. Chen X, Weber C, Farrell ET, Alvarado FJ, Zhao YT, Gomez AM, Valdivia HH. Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes. J Mol Cell Cardiol 114, 199-210 (2018). [Link]
  5. Cerrone M, Montnach J, Lin X, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Mancias A, Alvarado FJ, Dolgalev I, Karathanos TV, Malkani K, Van Opbergen CJM, Van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, Van Veen TAB, Valdivia HH, Delmar M. Plakophilin-2 is required for transcription of genes that control calcium cycling: a novel arrhythmia mechanism in arrhythmogenic right ventricular cardiomyopathy. Nat Comm 8, 106 (2017). [Link]
  6. Zhao Y.T., Valdivia C.R., Gurrola G.B., Powers P.P., Willis B.C., Moss R.L., Jalife J. & Valdivia H.H. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function. Proc Natl Acad Sci U S A 112, E1669-77 (2015).  [Link]
  7. Tong C.W., Wu X., Liu Y., Rosas P.C., Sadayappan S., Hudmon A., Muthuchamy M., Powers P.A., Valdivia H.H. & Moss R.L. Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or beta1-Adrenergic Stimulation. Circ Heart Fail 8, 595-604 (2015).  [Link]
  8. Loaiza R., Benkusky N.A., Powers P.P., Hacker T., Noujaim S., Ackerman M.J., Jalife J. & Valdivia H.H. Heterogeneity of ryanodine receptor dysfunction in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circ Res 112, 298-308 (2013).  [Link]
  9. Zhang H., Makarewich C.A., Kubo H., Wang W., Duran J.M., Li Y., Berretta R.M., Koch W.J., Chen X., Gao E., Valdivia H.H. & Houser S.R. Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res 110, 831-40 (2012).  [Link]
  10. Altschafl B.A., Arvanitis D.A., Fuentes O., Yuan Q., Kranias E.G. & Valdivia H.H. Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. J Physiol589, 6063-80 (2011).  [Link]
  11. Gurrola G.B., Capes E.M., Zamudio F.Z., Possani L.D. & Valdivia H.H. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel) 3, 1093-1107 (2010).  [Link]
  12. Schwartz E.F., Capes E.M., Diego-Garcia E., Zamudio F.Z., Fuentes O., Possani L.D. & Valdivia H.H. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors. Br J Pharmacol 157, 392-403 (2009).  [Link]
  13. MacDonnell S.M., Garcia-Rivas G., Scherman J.A., Kubo H., Chen X., Valdivia H. & Houser S.R. Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808. Circ Res 102, e65-72 (2008).  [Link]
  14. Benkusky N.A., Weber C.S., Scherman J.A., Farrell E.F., Hacker T.A., John M.C., Powers P.A. & Valdivia H.H. Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor. Circ Res 101, 819-29 (2007).  [Link]
  15. Altschafl B.A., Beutner G., Sharma V.K., Sheu S.S. & Valdivia H.H. The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta 1768, 1784-95 (2007).  [Link]
  16. Rueda A., Song M., Toro L., Stefani E. & Valdivia H.H. Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells. J Physiol 576, 887-901 (2006).  [Link]
  17. Zhu X., Zamudio F.Z., Olbinski B.A., Possani L.D. & Valdivia H.H. Activation of skeletal ryanodine receptors by two novel scorpion toxins from Buthotus judaicus. J Biol Chem 279, 26588-96 (2004).  [Link]
  18. Zhu X., Ghanta J., Walker J.W., Allen P.D. & Valdivia H.H. The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain. Cell Calcium 35, 165-77 (2004).  [Link]
  19. Farrell E.F., Antaramian A., Benkusky N., Zhu X., Rueda A., Gomez A.M. & Valdivia H.H. Regulation of cardiac excitation-contraction coupling by sorcin, a novel modulator of ryanodine receptors. Biol Res 37, 609-12 (2004).  [Link]
  20. Farrell E.F., Antaramian A., Rueda A., Gomez A.M. & Valdivia H.H. Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem 278, 34660-6 (2003).  [Link]
  21. Lokuta A.J., Komai H., McDowell T.S. & Valdivia H.H. Functional properties of ryanodine receptors from rat dorsal root ganglia. FEBS Lett 511, 90-6 (2002).  [Link]
  22. Jiang M.T., Lokuta A.J., Farrell E.F., Wolff M.R., Haworth R.A. & Valdivia H.H. Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res 91, 1015-22 (2002).  [Link]
  23. Zhu X., Gurrola G., Jiang M.T., Walker J.W. & Valdivia H.H. Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors. FEBS Lett450, 221-6 (1999).  [Link]
  24. Gurrola G.B., Arevalo C., Sreekumar R., Lokuta A.J., Walker J.W. & Valdivia H.H. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor. J Biol Chem 274, 7879-86 (1999).  [Link]
  25. Lokuta A.J., Meyers M.B., Sander P.R., Fishman G.I. & Valdivia H.H. Modulation of cardiac ryanodine receptors by sorcin. J Biol Chem 272, 25333-8 (1997).  [Link]
  26. Gomez A.M., Valdivia H.H., Cheng H., Lederer M.R., Santana L.F., Cannell M.B., McCune S.A., Altschuld R.A. & Lederer W.J. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276, 800-6 (1997).  [Link]
  27. Valdivia H.H., Kaplan J.H., Ellis-Davies G.C. & Lederer W.J. Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science 267, 1997-2000 (1995).  [Link]
  28. Lokuta A.J., Rogers T.B., Lederer W.J. & Valdivia H.H. Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism. J Physiol 487 ( Pt 3), 609-22 (1995).  [Link]
  29. el-Hayek R., Lokuta A.J., Arevalo C. & Valdivia H.H. Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms. J Biol Chem 270, 28696-704 (1995).  [Link]
  30. Valdivia H.H., Martin B.M., Ramirez A.N., Fletcher P.L. & Possani L.D. Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann. J Biochem 116, 1383-91 (1994).  [Link]
  31. Fuentes O., Valdivia C., Vaughan D., Coronado R. & Valdivia H.H. Calcium-dependent block of ryanodine receptor channel of swine skeletal muscle by direct binding of calmodulin. Cell Calcium 15, 305-16 (1994).  [Link]
  32. Valdivia H.H., Martin B.M., Escobar L. & Possani L.D. Noxiustoxin and leiurutoxin III, two homologous peptide toxins with binding properties to synaptosomal membrane K+ channels. Biochem Int 27, 953-62 (1992).  [Link]
  33. Valdivia H.H., Kirby M.S., Lederer W.J. & Coronado R. Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle. Proc Natl Acad Sci U S A 89, 12185-9 (1992).  [Link]
  34. Coronado R., Kawano S., Lee C.J., Valdivia C. & Valdivia H.H. Planar bilayer recording of ryanodine receptors of sarcoplasmic reticulum. Methods Enzymol 207, 699-707 (1992).  [Link]
  35. Valdivia H.H., Hogan K. & Coronado R. Altered binding site for Ca2+ in the ryanodine receptor of human malignant hyperthermia. Am J Physiol 261, C237-45 (1991).  [Link]
  36. Valdivia H.H., Fuentes O., el-Hayek R., Morrissette J. & Coronado R. Activation of the ryanodine receptor Ca2+ release channel of sarcoplasmic reticulum by a novel scorpion venom. J Biol Chem 266, 19135-8 (1991).  [Link]
  37. Valdivia H.H., Valdivia C., Ma J. & Coronado R. Direct binding of verapamil to the ryanodine receptor channel of sarcoplasmic reticulum. Biophys J 58, 471-81 (1990).  [Link]
  38. Valdivia H.H. & Coronado R. Internal and external effects of dihydropyridines in the calcium channel of skeletal muscle. J Gen Physiol 95, 1-27 (1990).  [Link]
  39. Valdivia H.H. & Coronado R. Inhibition of dihydropyridine-sensitive calcium channels by the plant alkaloid ryanodine. FEBS Lett 244, 333-7 (1989).  [Link]
  40. Valdivia H.H., Smith J.S., Martin B.M., Coronado R. & Possani L.D. Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel. FEBS Lett 226, 280-4 (1988).  [Link]
  41. Valdivia H.H., Dubinsky W.P. & Coronado R. Reconstitution and phosphorylation of chloride channels from airway epithelium membranes. Science 242, 1441-4 (1988).  [Link]